Complete and Utter Idiots Guide to Sending an Email Essay Example for Free

Complete and Utter Idiots Guide to Sending an Email Essay This may seem like a completely impossible task, but trust me, it’s easy. An everyday completely normal task for most people, but you are not most people, are you? Well, there’s one thing you must do. We are assuming you already own a computer and have an email, so the first thing that is vital in this†¦ find your computer. I know! You have to get up, use those long things on the end of your body made for walking, and look. No†¦ that’s the telly. We are looking for something that looks like a smaller telly with a keyboard and a mouse. No, no, no! Not a real mouse! Now get down from your sofa and look for a screen. Yes, that’s it! Gosh, if it takes you this long to find your computer this is going to be a long day. Congratulations! Now, as you are looking at the computer, sit down on the chair in front of it. Sit on the seat, not the top, bottom or legs, on the actually seat. Yes, that’s a bit more comfy isn’t it? I hope your computer is in fully working order? Supposing that it is, you need to find a big button that turns your computer on. No, that opens up the CD drive. Don’t push it back in! Press the button again so you don’t break it. Oh my, look! It’s right in front of you on that big box. Woohoo! You found it, now login using your password that you thought up so you would remember it. Yes, it is the word written on the sticky note stuck to the wall above you. Now, the long oblong in front of you, that’s your keyboard. No, an oblong is another word for a rectangle†¦ a long square? Yes, the thing with the buttons. Now, press the buttons with the letters/numbers/punctuation that are identical to the ones written on your sheet. Yes, you have to write them in the same order, otherwise itswrong. Thank the lord, you’ve logged on! You’ve just achieved something in your life! Be proud, be very, very proud. The next ‘impossible’ task you have to face is finding the internet icon and using your mouse to click on it. We have already established that this is not a real mouse, so calm down. Now, your computer screen will generally look like this: This may look big and scary but it’s simple really, if you just listen. As you probably don’t know, there are different types of internet service providers. The most common one is internet explorer which is automatically downloaded onto most computers. So we will just stick with that one. The symbol is a blue E. found it? No, that’s not it†¦ yes, the blue E. Good.

Looking At The Effects Of Online Gaming

Looking At The Effects Of Online Gaming Introduction In order to find out a relation between online games and various aspect of players life such as learning, behaviour, social life, and others, many studies have been done. When considering, how can online gaming effect on the player, we come to the four main domains. These are learning in the game based environment, relation between violent games and aggressive behaviour, minors and inappropriate content and addictive behaviour. Aim of this essay is to focus on game addiction as it itself affects many aspects of the life. What motivates player to play and why some players become addicted whilst others do not? Further, what from psychological point of view makes the games addictive and what addiction is? Also aim is to identify differences between game genres and the amount of time they are being played and to answer question if and why online games are becoming so much more popular then games played offline. Is an interaction with other people the only reason? LITERATURE REVIEW If there is speech about addiction, there is also need to mention a motivation. As these two go hand in hand. There is no game addict, who has no motivation to play. First to mention is Bartles model (Seay, 2006) of types of players. It defines four types of players and their specific motivations. They are : achiever, explorer, killer and socializer [see appendix C for explanation]. Yee later derived five motivational facets as opposed to Bartles player types. (Seay 2006, Yee 2002) They are : relationship, immersion, achievement, grief, leadership. [see appendix C for explanation]. These were further modified and are being referred to as Facets ÃŽÂ ± (Seay, 2006) They are : Achievement players place an emphasis on feeling like and being regarded by others as accomplished players. Escapism players value gaming as an opportunity to get away from the pressures of the real world. Role playing players enjoy the fact that gaming allows them to become part of a fantasy world. Manipulation manipulation players are characterized by a desire to annoy and exploit other players. Relationship Relationship players are attracted to the social aspects of gaming. [for full description see Appendix] Challenge and skills are interrelated and the diagram below helps to understand difference between online and offline games in relation to addiction. (Hernà ¡ez, 2006) used this diagram based on the study of psychologist Csikszentmihalyi, to demonstrate relation between skills and challenge. According to Csikszentmihalyi (1990) flow is the state in which people are so intensely involved in an activity that nothing else seems to matter; the experience itself is so enjoyable that people will do it even at great cost, for the sheer sake of doing it. If applied on video game, it is clear that game should increase challenge equally to players skill, to keep the player within the flow. According to annual report (Nielsen 2008) 56% of light gamers and 78% of heavy gamers play online games. In most offline games the difficulty is set at the start and will remain on the same level till the end of the game. What leads to player moving from flow to control and eventually to boredom, when he losing interest. Whereas online games, particularly massively multiplayer online role playing games (MMORPGs) are designed to keep player in the flow by increasing challenges accordingly to abilities. MMORPGs are most often connected to the game addiction. Yee 2002 wrote about attraction and motivation factors of MMORPG games. Motivations are mentioned above, so lets explain attraction factors. There are three main attraction factors of mmorpg that encourage time investment and personal attachment. Briefly these are : Inherent reward cycle player is always close to some reward, whether it is level, skill or quest Network of online friends that player accumulates over time. They encourage playing to remain at the same level so they can keep playing together Immersive nature of virtual environment which encourage players to become attached to their virtual characters and tries to enchant player with a fantasy, and make him feel that he is part of something grand and extraordinary Parker 2009 defines addiction as : psychological disorder that affects the way the brain functions by impacting chemical processes related to motivation, decision making, learning, inhibitory control, and pleasure seeking. Behavioural addictions like gambling and sex are forms of psychological dependence; addictions to substances like drugs and alcohol are forms of both psychological and physical dependence. [ for full description see appendix B] When it comes to particular effects as a consequences of addictive behaviour these can be divided into two categories. First is the one which contain physiological consequences, which are mostly the same as with general excessive use of computer whatever the reason (work, games, internet..) and these count back problems, dry eyes, repetitive stress injuries, negative changes in sleep patterns, irregular eating, leading to starvation or obesity, and drowsiness and depression of immune system from lack of sleep (Grabianovski, 2010). These are the same for everyone. The second category represents psychological effects. These are mainly connected to change in the social life of the player and may be various for every player, depending on what type of player it is and what are his motivations for playing. Seay 2006 assumes that players driven by achievement and escapism are most likely to get addicted. Low ability of self regulation is another factor contributing to addictive behaviour. Bandura (1999 cited in Seay 2006, p. 44-45) defines in his social cognitive theory term self-regulation as : the ability of an individual to manage his own behaviour through observation, evaluation, and consequation. Increased amount of play hours leads to loneliness, decreased social support and decreased size of social network (Seay, 2006. p. 54) and these factors contribute to development of depression. Freeman 2006 defines massively multiplayer online role-playing games as : a particular genre of online games in which players from around the world create their own characters that interact with other players in the games virtual world. Players gain points with which to buy powers and advance in the never ending game played in real time. As all players are consistently improving the challenge for others remains on high level even when playing for long time. RESEARCH METHODOLOGY Data were collected for the research through questionnaire, because aim was to get a larger amount of quantitative data rather than smaller amount of qualitative data. Twenty five participants (six women) aged in range between eighteen and thirty one years participated. Questionnaire was made anonymous and self-administered in order to maximize rate of honest answers, since some people may feel embarrassed for their answers and thus prefer to answer not honestly if identity is known or when talking face to face on interview. Care was taken to avoid questions, which could cause embarrassment, anger, sadness or frustration. Idea of using observation seems to be not appropriate at all, since it is very time consuming and natural behaviour of observed participant is very questionable. The questions used are closed except of two. Because of the nature of questions, three of them contain option of multiple answers. Reason is to make it easier for participants, by listing the most expected answers and add field for other__ answer, for the case appropriate answer was not included in the list, rather than make question opened. Likely participants would instead of writing full list of their reasons just leave some out. Open question is No.5, which asks for reason why participant prefer online games as this may be more very specific reasons. Also question No.8 is open, asking participant for three favourite games. Purpose is to determine favourite games genre in relation to playing time. To confirm that online MMORPG are most popular among heavy players. To get a further information relating to motivations, it would be useful if participants filled out a online test for Bartles types. DESIGN METHODOLOGY Idea was to prove that mmorpg games are most popular among heavy and hard-core players, as they cover motivation elements of all four player types defined in Bartles model. Further to identify what are the factors, that lead player to addictive behaviour. RESERACH RESULTS Three quarters of participants stated they prefer to play online games. More than one third play video games for more than 15 hours a week. More than half of them consider main reason to be higher challenge and nearly the same number stated the reason to be socializing with people online. Other reasons occur only marginally. See appendix A for charts. EVALUATION OF RESULTS The main reason for playing online games in general is higher challenge, what matches with Csikszentmihalyis diagram and adds credit to its validity. The most popular game played online is first person shooter, but when it comes to hardcore players the mmorpg games become dominant. MMORPG offer open end gameplay in virtual world which is virtually endless, that is the reason why, heavy (more skilled) players are more engaged in online games. Half of the participants for this research, play for less than 8 hours a week, so it is hard to demonstrate relation between playing time and mmorpg online games based on data gathered. But comparison was done to demonstrate what part of these occasional or light players play MMORPG games online. Not surprisingly very small part [see chart 4, appendix A]. On question what aspects of life are most affected by playing, the mostly affected are other hobbies and sleep. This was also predictable, when taken to account that number of heavy players FINDINGS AND RECCOMMENDATIONS Increasing popularity of online games is related to Csikszentmihalyis diagram, which defines the flow (challenge/skill). This is what players look for in games and find mostly in online virtual environments (mmorpg). CONCLUSION Game addiction is very dangerous and may lead to social isolation, broken relationship, divorce, job loss, health problems and depression. Well designed MMORPG contain elements for every player type so, whoever plays it, whatever the motivation is, it is somehow included, that is why these games are most addictive.

Types of Poisonous Snakes and Snake Venom

Types of Poisonous Snakes and Snake Venom In the fourth century BC, India was invaded by Alexander the Greats army, which was accompanied by a number of Macedonian physicians and observers. They were impressed by the achievements of the local Ayurvedic practitioners, particularly in the treatment of snake bite (1). Unfortunately, the legacy of ancient skills, experience and wisdom may have held back rather than encouraged the application of modern scientific research methods to manage this continuing scourge of rural life in India (2).In India, snake envenomation is a huge public health problem, but unfortunately it hasnt got its due attention. There is scant information on epidemiology and minimal research on anti venom. Most of the quoted figures on snake bite are hospital based though most bites occur in villages and among poor population, who rely largely on traditional treatment. Recent Global Snake Bite Initiative of the International Society on Toxicology and by the World Health Organisation, is expected to throw more light on epidemiology and treatment of snake bites (3). Of the 3,000 or so snake species that exist in the world, only about 15% are venomous. Venomous snakes exist on every continent except Antarctica. In India the Big Four (Cobra, Krait, Saw scaled and Russels viper) are the key poisonous snakes(4).Though the hospital records show only 1,300 annual deaths but a recent Nationally Representative Mortality Survey puts this figure to approx. 45,900 deaths a year. Snakebite remains an underestimated cause of accidental death in modern India. Community education, appropriate training of medical staff and better distribution of antivenom, especially in the states with the high prevalence, could reduce snakebite deaths in India(5). Historical Background: Since time immemorial snake has been an object of worship in many countries. According to Hindu mythology this world is resting on a many-headed cobra. Lord Vishnu lies on Sheshnag. The Cobra coils around Lord Shiva. Old Egyptian nobility are pictured with cobra hood on their forehead. Some cultures held snakes in high esteem as powerful religious symbols. Quetzalcoati, the mythical plumed serpent was worshipped as the master of life by ancient Aztecs of Central America. Some African cultures worshipped rock pythons and considered the killing of one to be a serious crime. In Australia, the Aborigines associated a giant rainbow serpent with the creation of life. In Jewish texts, in the old Maya civilization, in Kundalini yoga, theosophy and in many medieval society emblems the world over, snakes form an essential symbol. This shows how intimate has been the historical, social and mythological association of snakes with the mankind and no wonder the cobra is wors hipped in India on Naga Panchami day. Ayurvedic texts written by Vagbhata and Sushruta, have given in fair detail the classification of snakes according to their symptoms and their poisoning. There are many stories about constrictors, particularly anacondas in the Amazon and pythons in the east, which are said to have strangled adult humans, these need to be treated with great deal of skepticism (6,7,10). In practice it is only the poisonous snakes that are of interest. Poisoning from snake bite is an important medical emergency in Africa, South America, India, Pakistan and greater part of south East Asia. Epidemiology As snake bite is not a notifiable illness, there is little reliable information on incidence of snakebite in many parts of the world. Snake bite is an important occupational injury affecting farmers, plantation workers, herders, and fishermen. Open-style habitation and the practice of sleeping on the floor also expose people to bites from nocturnal snakes. Bites are more frequent in young men, and generally occur on lower limbs. The incidence of snake bites is higher during the rainy season and during periods of intense agricultural activity (6). Available data shows 30,000-40,000 deaths from snakebites every year but this figure probably is an underestimate (8), because of incomplete reporting. Recent global estimates suggest 2.5 million bites and 85000 annual deaths. In India recent published literature suggests yearly 45,900 deaths due to poisonous snakebites and 5.6-12.6 deaths per 100,000 population in some states appears to be realistic(4,5). Upto 80% of snake bite patients in developing countries, first contact traditional practitioners, before visiting a medical center (6,7,9). Owing to the delay in reaching hospital many patients die enroute. Going by the fact that around 85-90 % snakes are non-poisonous and even 50% of bites by poisonous snakes are dry runs, number of snakebites in India are enormous(4). Myanmar probably has highest mortality figure in Asia, where over 70% bites are by Russells viper. In India, Maharashtra records the highest number of snakebites, followed by West Bengal, Tamil Nadu, Uttar Pradesh and Kerala. In Maharashtra alone, 70 bites per 100,000 population occur yearly with 2.4 per 100,000 mortality. Rajasthan and Jammu region of JK also report large number of viper bites (up to 95% of all bites (10). During rains and floods number of cases shows a steep rise. Most bites occur between 0400 hours to midnight and mere observation that majority of bites are on lower extremity suggest that snake is inadvertently trodden upon. In India 2/3rd of bites are due to saw scaled viper, about 1/4th due to Russells and a smaller proportion due to cobra and Krait. In neighboring Sri Lanka Daboiarussellii accounts for 40% and in Myanmar 70% of snake bites (11,12). For correct epidemiological studies one requires enzyme-linked immunosorbent assay to identify antigen and antibody. This permits reliable identification and sensitive quantification of venom antigens and antibody. Natural antibody is detectable in serum by one week of bite, which rises to peak by one year and falls to low levels by 3 years, though may be detectable for up to 40 years after bite. Anti snake venom reduces but doesnt abolish the generation of antibodies. In some countries e.g. Australia, ELISA is routinely used for identification of poison (13). Anatomy and Habits Snakes belong to order Ophidia of the Reptilia general class. Over 3000 species are encountered in the world of which less than 15% are poisonous. Most of these are found in tropical and subtropical regions, Australia and throughout USA except in Alaska, Maine and Hawaii. In India 216 species from 9 families are reported of which 52 species from 3 families are poisonous. Most snakes are non-venomous, have no fangs and belong to colubrid family; a few colubrids are technically poisonous having a venom gland connected to a solid fang at the back of mouth. Bites from back fanged colubrids are generally harmless to man but with some species like African boomslang, Dispholidustypus, serious and even fatal poisoning has been reported in the snake handlers(13). The three families of front fanged poisonous snakes are elapids, vipers and sea snakes. Elapids are land snakes with non-mobile 3-5 mm long fangs in adults. Vipers have 10-30 mm long fangs which are easy to see when erected, but diff icult to see when folded against upper gum. Vipers are divided into crotalids or pit vipers who have heat sensing pit between eye and nose and viperidae which dont have the pit. Sea snakes have very short immobile fangs and flat rudder like tails. There are mainly 4 poisonous snakes encountered in India i.e. Cobra, Krait, Saw scaled and Russells viper. New addition to Big Four is Hump-nosed Pit viper (Hypnale hypnale), recently being reported from India though existent for more than 100 years(16). This has been mistaken for Saw Scaled Viper by most. It is identified by larger, triangular head ending in a snout with large scales on the head in contrast to the small scales of saw scaled viper. The envenomation is manifested by coagulopathy and renal failure. It is reported as one of the most poisonous snakes in India but specific anti venom against this is not available (12). Common poisonous snakes found in India are as below; Viperidae * Saw scaled viper (Echis carinatus) * Russells viper (Vipera russelli) Elapidae * Indian Cobra (Naja naja) * Common Krait (Bungarus caeruleus) Crotalidae * Pit Viper Hydrophidae * Sea snakes Cobra is 1.2-2.1 meters long while King Cobra may be as long as 5.5 meters. Cobra is usually slate gray to brown. The back of hood may or may not have a pattern. They raise their hood when aroused or threatened. They try to avoid mankind unless they are too close or are trodden upon. The distance a cobra can strike in forward direction is the height its hood rises above the ground. Some cobras however can spit venom upto a distance of 3 meters. This can cause redness, corneal abrasions/ulcers etc. King cobra is uniformly olive, brown or green with ringlike cross bands of black. Although it is the largest venomous snake in the world but it avoids attacking another venomous snake for fear of being bitten, therefore it feeds only on harmless species. Females build a nest and then deposit the eggs. Lying close by, she guards the nest and is highly aggressive towards anything which approaches the nest.The king cobra is found in the forests or their vicinity in the Himalayas, Bengal, Assam and South India. The common Indian cobra is found in jungles but also in open country with or without vegetation; in gardens, drains, cultivated fields, and populated areas in mans proximity; in stacks of wood and under rubbish, in loose masonry, crevices of walls and building ruins; in old cemeteries, in temples or mosques.It is often seen in dark corners of bathrooms, stables and servant quarters of old bungalows. It may be found in old hole of a tree, in ant-hill or a rat burrow. It can climb trees and swim well. It feeds on rats, mice, frog; less frequently on birds or their eggs; and sometimes on chickens, squirrels, lizards and other snakes. It is usually diurnal in habit but in populated areas it is more nocturnal(14,15). Krait is black or bluish black with white narrow crossbands and a narrow head. Its average length is 90cm 150 cm. It is found only in Asia. It is active during night and passive during the day. It is found in plains, cultivated fields and human habitations. It has tendency to seek shelter in sleeping bags, boots and tents.Kraits are mostly found in Eastern India, Assam, Bengal and parts of South India and patches all over the country. There are two varieties, banded and non-banded. Although it has most potent venom of all land snakes, it is rather shy and bites human beings least commonly (13,15). Vipers are so called because they are viviparous. There are 110 kinds of vipers and all are poisonous. Vipers have broad plates extending right across the belly and small scales on the head similar to those on the body. Body is light brown and their back is usually covered with black blotches of inverted V shaped markings. Some of the pit vipers have large shield on the head. Russells viper or Daboia is a big stumpy snake  ½-2 meters long with short tail and characteristic marking as described above. It is irritable. When threatened it coils tightly, hisses and strikes with a lightning speed, that victim has no chance of escaping. Indian pit vipers are generally found in hilly areas of Western Ghats and Sunderbans in West Bengal.Russells viper prefers open country, cultivated fields and bushy or grassy fallow lands. It is nocturnal in habit. It is commonly found in plains of Punjab, Bombay, Madras area and Brahamputravalley(4,6,20). Saw scaled viper (Echiscarinatus) is found all over India but particularly in Western India, Punjab, and around Tiruchirapalli. It prefers open dry rocky country or arid deserts.Saw Scaled Viper (Phoorsa) is responsible for maximum bites and deaths all over the world than any other snake. This small stumpy snake measures 25-60cmand camouflages well with the surroundings. Colour is light buff with shades of brown, dull red or gray. Its sides have a white or light coloured pattern. Its head usually has dark stripes that start behind the eye and extend to the rear. It gets its name from the fact it rubs its own body from sides and produces rasping sound. This ill- tempered snake attacks any intruder. It is common in rural settlements, cultivated fields and regions, barns, and rock walls(4,14). Sea snakes resemble cobra and its allies in structure of their fangs and most other characters. Most of them are 3-4 ft. long, and a few may attain a length of 8 feet. Their tails are laterally flattened and are sculled in paddle -like fashion during swimming. Most sea snakes are covered with small round scales and lack the enlarged ventral scales found in terrestrial species. The nostrils are valvularand hey can be closed when snake submerges- and may be displaced towards the top of the head. Excess salt from the sea water and diet is excreted through special glands in the snakes mouth. Venomous sea snakes mostly inhabit the waters of Australia, Indonesia, Southeast Asia and India. Of the more than 50 species some are many times more poisonous than land snakes, with venom 10-40 times more potent than that of cobra. Except for a single species found in creeks and river estuaries sea snakes are all poisonous. They however have a narrow gape and rarely bite effectively.Their bite is re latively painless and, amazingly very low percentage of patients suffer significant envenomation during the attack. In a census in Malay Peninsula less than 25% developed features of poisoning and a small percentage became critically ill (4,12,14). Snakes have a good sensory perception with primitive ears. Their vision is limited to few meters only, with better acuity for moving objects. Lower jaw is a pair of bones joined together centrally by an elastic ligament which doesnt articulate with maxilla thus enabling the snake to swallow its prey as a whole. Fangs are modified teeth on pre maxilla. Venom is secreted from parotid glands and is meant to immoblise the small creatures like rat. Man is an innocent coincident victim. Bite is a well coordinated act involving movement of head and body. It involves coordinated positioning of head, opening of mouth, attack by forward thrust of body and head, piercing the skin by fangs and injecting the venom while the wound is deepened by contraction of temporalis muscle. Vipers have holes at the tip of fangs while elapids have gutters in the fangs(14,15). Identification of Poisonous Snakes Most of the bites are by non-poisonous snakes, but the intense fear of snake bites may cause acute panic reaction or feeling of impending death. If the patient has brought snake to the attending doctor, proper identification can help institute early and appropriate treatment to the victim and also alleviate undue emotional disturbance. Some of the important differentiating features of poisonous from non-poisonous snake are appended below(13,18). (a) Fangs: The most distinctive feature of poisonous snakes is the fangs. These are modified teeth in the upper jaw, generally two in number, one on either side. They communicate with salivary glands and are hollow or grooved. In elapidae and sea snakes they are located in front, are short and immobile while they are large, curved and have wide range of movement in vipers. (b) Scales on Belly: In poisonous snakes the belly scales are large and extend all across the belly. In non-poisonous snakes belly scales are small and generally dont extend across the belly. (c) Head: Vipers have heavier triangular head with small scales all over. In case of pit vipers a pit is located between the nostril and the eye. Cobra and Krait have large head scales. In cobra upper third labial is largest and touches the eye and nasal shield. In Kraits upper third labial does not touch the eye and nose, but the fourth lower labial scale on the under surface of mouth is the largest. All the poisonous sea snakes have large scales on the head and valved nostrils. (d) Pupil: Poisonous snake have generally elliptical or vertical slit. However pupils are round in elapidae (cobra) and most non-poisonous snakes. (e) Body design: Krait has central row of large scales on dorsal side, which are almost hexagonal. It has paired white or black stripes across the body in the banded Krait. Some cobras have spectacle-like mark on their hood. (f) Fang marks: In non-poisonous snakes since all teeth are at same level so bite is stretched and bite marks are along a curved line i.e. row of bites,as in human bite. Bite site can be easily made out. In poisonous snakes since poisonous teeth are generally two (fang marks) and other teeth areat lower level, so only two,1-2 cm spaced puncture marks are seen. A distance of less than 10 mm signifies a small snake while a distance of over 15 mm is suggestive of a large snake. Sometimes one requires hand lens to identify these marks especially in cases of cobra or Krait bite. It is noteworthy that the size of the venom fangs has no relation to the virulence of the venom. The comparatively innocent Indo-MalayLachesis  have enormous fangs, whilst the smallest fangs arefound in the  Hydrophids  which possess very potent venom. (g) Sound: Most venomous snakes produce characteristic sounds, which may also help in recognition of snake. Russells viper produces Hissing, saw scaled viper Rasping and King Cobra Growling sounds. Easy identification of different snakes is as follows: Cobra: Hood while alive, large scales on head. Pupil is round and 3rd upper labial touches the eye and nostril. Large belly scales extend acrossthe width. Krait : The fourth lower labial scale on the under surface of the mouth isthe largest. Hexagonal large scales in the central row on dorsal side. Body may be banded. Belly scales extend across the width. Viper : Triangular heavy head with small scales all over. Large belly scales extend across the width. Snake Venom Snake venoms are the most complex of all natural venoms and poisons. The venom of any species might contain more than 100 different toxic and non-toxic proteins and peptides, and also non-protein toxins, carbohydrates, lipids, amines, and other small molecules. The toxins of most importance in human envenoming include those that affect the nervous, cardiovascular, and haemostatic systems, and cause tissue necrosis (21). Snake venom is primarily meant to paralyse the prey, man is only accidental victim to whom snake strikes if threatened. Proteins constitute 90-95% of venoms dry weight and they are responsible for almost all of its biological effects. Venom is made up of toxins, nontoxic proteins (which also have pharmacological properties), and many enzymes especially hydrolytic ones.  Enzymes (molecular weight  13-150 KDa) make-up 80-90% of viperid and 25-70% of elapid venoms: digestive hydrolases, L-amino acid oxidase, phospholipases, thrombin-likepro-coagulant,andkallikrein-like serine proteasesand  metalloproteinases  (hemorrhagins), which damage vascular endothelium. Polypeptide  toxins (mol weight 5-10 KDa) include  cytotoxins,  cardiotoxins, and postsynaptic neurotoxins (suchas  ÃƒÅ½Ã‚ ±-bungarotoxin  and  ÃƒÅ½Ã‚ ±-Cobratoxin). Compounds with low molecular weight (up to 1.5 KDa) include metals, peptides, lipids, nucleosides, carbohydrates, amines, and oligopeptides, which inhibit angiotensin converting enzyme (ACE) and potentiate bradykinin (BPP).  Phosphodiesterases  interfere with the preys cardiac system, mainly to lower the  blood pressure.  Phospholipase A2  causes  hemolysis  by lysing the  phospholipid  cell membranes  of  red blood cells.  Amino acid  oxidasesand  proteases  are used for digestion. Amino acid oxidase also triggers some other enzymes and is responsible for the yellow colour of the venom of some species.  Hyaluronidase  increases tissue permeability to accelerate absorption of other enzymes into tissues. Some snake venoms carry fasciculins, like the  mambas  (Dendroaspis), which inhibit  cholinesterase  to make the prey lose muscle control (22,23). The most lethal venoms are those of elapids and sea snakes. These toxins are rapidly absorbed into the blood stream thereby causing rapid systemic effects. Large molecular weight viper toxins are absorbed slowly through lymphatics thereby staying longer at local site, hence more local effects. Pathophysiology of ophitoxemia is basically dependent on disruption of normal cellular functions. Some enzymes like hyaluronidase disseminate venom by breaking down tissue barriers. Ophitoxemia can lead to increase in vascular permeability thereby causing loss of blood and plasma volume in extravascular space. Collection of this fluid is responsible for edema and fluid loss, if significant it can lead to shock. Venom also has cytolytic effect leading to necrosis and secondary infection. Neurotoxic effect may lead to paralysis, cardiotoxic effect can cause cardiac arrest and likewise myotoxic or nephrotoxic effect can lead to rhabdomyolysis and renal failure. Ophitoxaemia also can lead to coagul ation disturbances. Among the various species, the lethal dose of venom, for cobra is 120 mg, Krait 60 mg and for Russells viper and saw scaled viper is 150 mg respectively. But clinical features and outcomes are not predictable as every bite does not cause complete envenomation. Pathological effects of venom may not be noticed until about six hours (varying between 1.5-72 hours), and it may remain functionally active causing persistent coagulopathy even after three weeks of bite. Hence duration of antigenemia is an important determinant for the extent of pathological effect. It has been unequivocally proved by studying the venom levels by enzyme linked immunosorbent assay (ELISA), that effects due to envenomation depend on venom hours (i.e. Blood venom level x time elapsed between bite and institution of treatment) rather than blood levels alone. Hence with the same level of venom, features due to envenomation may become progressively severe with passage of time (14,20). There are four distinct types of venom effects: Proteolytic  venom  dismantles the molecular structure of the area surrounding and including the bite. Hemotoxic  venoms  act on the heart and cardiovascular system. Neurotoxic  venom  acts on the nervous system and brain. Cytotoxic  venom  has a localized action at the site of the bite. Pathophysiology of various biological effects of snake envenomation The following few paragraphs shall describe the biological effects of venom. (a) Local Swelling: Most viper bites cause local swelling at the site of bite, which starts within minutes of bite and massive swelling of the limb may develop within 48-72 hours. This is usually the result of hemorragins in the venom. This opens the endothelial pores resulting in leakage of plasma or whole blood. At times leakage may be so much that patient develops hypovolemic shock. This swelling is not due to any venous occlusion or infection. If the exudation is of whole blood, then later discoloration of the limb may develop. In contrast to Echis, in European adder V berus bites, spontaneous bleeding is rare but discolouration is common. Sometimes local swelling is delayed and compartment syndrome may result(10,13,17). (b) Local Necrosis: In viper bites local necrosis appears late if at all and if it occurs, it is due to ischemia, mimicking dry gangrene. On the other hand in Cobra bite local necrosis appears early. Local swelling may develop after 2-3 hours but necrosis develops rapidly after that. It is due to cytolytic factors present in the venom and is a wet gangrene. As this dead tissue provides ideal setting for anaerobes, hence the putrid smell. An early excision is warranted (13). (c) Non-specific early symptoms: With bites of some vipers e.g. V berus, V xanthina, Australian elapids, some rattle snakes etca few symptoms are common. Vomiting, headache, abdominal pain, explosive diarrhea and collapse can occur. These features resolve in 30-60 minutes, suggesting activation of kinin system followed by inhibition of bradykinin (13,17). (d) Shock: It can develop due to extensive volume leak from vessels in cases of viper bite. It can result even before a limb gets swollen. Pulmonary intra vascular clotting, pulmonary edema and cardiac effects can be contributory factors for shock. (e) Spontaneous haemorrhage: Haemorrhages can develop in patients with viper bites even days after the bite. These at times may be life threatening especially if they occur in brain. Local blisters at bite site appear to be depot of venom, which dont get targeted by anti snake venom. Therefore one must keep in mind the delayed absorption from bite site in patients who present with late bleeding manifestations despite having been given anti-snake venom a few days back. (f) Effect on Circulation: Some viper venoms contain procoagulant activity which activates prothrombin to thrombin; which in turn converts fibrinogen to fibrin while in others procoagulant venom may directly affect fibrinogen. This fibrin formed is susceptible to lysis unlike natural fibrin thus resulting in poorly clottable or non-clottable blood because of absent or very low levels of fibrinogen. It should be remembered that bleeding manifestations during envenomation are not generally due to coagulation disturbances but rather due to haemorrhagin. Platelet count may also be low though usually it is normal. Low platelet count is due to consumption of platelets in the repair of endothelial damage. Polymorphonuclearleucocytosis is common in all forms of envenomation especially severe envenomation. Both viper and elapidae bite may have hemolytic activity in vitro but abnormal hemolysis is rarely of clinical importance except probably in renal failure (13,17). (g) Renal Failure: Renal failure is a common manifestation of viperine envenomation especially where treatment has been delayed. On renal biopsy acute tubular necrosis is the commonest underlying lesion in 50-70% of cases and acute cortical necrosis (patchy / diffuse) has been found in 20-25% of cases. Hypovolemia and shock are the usual underlying mechanism. Other contributory factors are hemo/ myoglobinuria, hemolysis, associated sepsis and disseminated intravascular coagulation (24). Glomerular lesions have also been described in snake bite cases. Merchant et al(25) have reported mesangial proliferation, splitting of basement membrane, swelling of endothelial cells and ballooning of glomerular capillaries, but the significance of these lesions in causing renal failure is not clear and is debatable. Seedat et al(26) reported two cases due to puff adder who developed oliguric renal failure and biopsy showed crescenticglomerulunephritis. Authors suspected hypersensitivity of venom as the cause. Occasional casesof severe glomerulonephritis related renal failure have been reported in the literature. Experimental studies carried out on the effect of Habu snake venom (found in Japan) has given some insight into understanding of the glomerular lesion. This venom contains hemorrhagin, like the venom of Echiscarinatus. Within 24 hours of injection of this venom destruction of mesangium occurs resulting in ballooning of capillaries which become packed with red cells and fibrin giving an appearance of blood cysts. This is followed by proliferation of mesangial cells giving appearance of segmental proliferative glomerulonephritis. Rarely crescents are observed. These studies provide evidence that these glomerular changes are due to vasculotoxic effects of hemorrhagin. However about tubular necrosis or cortical necrosis, the commonest lesion encountered in snake envenomation, there is no consensus that venom has any direct toxic effect in producing these lesions (27,28). (h) Neurotoxic effects: Elapidae venom and sea snake venom cause neurotoxic effects due to neuromuscular blockade. Commonly affected muscles in elapidae bite are those of eye, tongue, throat and chest (leading to respiratory paralysis in severe envenomation). Neurotoxins are small molecular weight positively charged molecules with less antigenecity. Neuro- muscular blockade is produced by one of the following mechanisms. (a) Post synaptic block (Cobra) cobratoxin and alpha-bungarotoxins act similar to d-tubocurarine on the post synaptic membrane. There is no decrease in acetyl choline. Response to neostigmine is satisfactory. (b) Pre-synaptic blockade (Krait)beta- bungarotoxin acts like botulism toxin pre synaptically to block the neuro-muscular junction. Post junctional membrane remains sensitive to acetyl choline. The time required for neuromuscular block varies with impulse traffic, therefore intense physical activity shortens the interval between envenomation and neuromuscular bl ock. Response to neostigmine is less satisfactory. It is important to note that these neurotoxins dont cross the blood brain barrier and therefore do not cause alteration in consciousness. Hence in case of altered sensorium an alternative cause should be found (23,29). (i) Cardiotoxic Effects: Cardiotoxin (Cobra) acts on cell membrane of skeletal, smooth and cardiac muscle to produce paralysis and cardiac asystole. Cobramine B and cytoxin cause irreversible depolarization of cell membrane and systolic cardiac arrest. Hyperkalemia following massive hemolysis or rhabdomyolysis also depresses cardiac function. (j) Myotoxic Effects: Although sea snake venom appears to be neurotoxic in animal experiments, the effects in man are primarily myotoxic. There is diffuse effect on all muscles though local effects at the site of bite are minimal. In humans bitten by sea snakes the findings are typical of generalized myopathic lesions in skeletal muscle. Damage to muscles- rhabdomyolysis and hyperkalemia resulting from it may be life threatening. Snake envenomation has so diverse effects that every system of the body is affected directly or indirectly (20,29). CONCLUSION Since ancient times snakes have been worshiped, feared or loathed in India. It is a common and frequently devastating environmental and occupational disease, especially in rural areas of our country. India has the highest number of death to snake bite in the world. One of the major gaps in the battle against snakebite in India is the lack of qualitative work. Most Herpetology text books give snake identification data that is overtly complex and of little use to doctors. Snakes are misidentified by doctors in most cases where snake is brought to the hospital. Without the snake, identification based on symptomatology is clearly fraught with problems. The doctors should be aware of discovery of a new poisonous snake, the Hump-nosed Pitviper (Hypnale Hypnale) which has no available antivenom at present. Community education, appropriate training of medical staff and better distribution of anti venom, especially in the states with the high prevalence, could reduce snakebite deaths in India .

Roethkes Use of Tone Essay -- My Papas Waltz Poems Poetry Essays

Roethke's Use of Tone   Ã‚  Ã‚  Ã‚  Ã‚  Childhood experiences seem to be the ones that are recollected most vividly throughout a person's life. Almost everyone can remember some aspect of his or her childhood experiences, pleasant and unpleasant alike. Theodore Roethke's poem "My Papa's Waltz" suggests even further that this concept could be true. The dance described in this poem illustrates an interaction between father and child that contains more than the expected joyous, loving attitude between the two characters. Roethke's tone in this work exhibits the blended, yet powerful emotions that he, as a grown man, feels when looking back on this childhood experience. The author somewhat implicates feelings of resentment fused with a loving reliance with his father.   Ã‚  Ã‚  Ã‚  Ã‚  For example, the first two lines of the poem read: "The whiskey on your breath/ Could make a small boy dizzy;" (Roethke 668). This excerpt appears to set a dark sort of mood for the entire rest of the poem. By the first two lines, the reader may already see how this man feels about his father's drunkenness. It seems as if Roethke has preceded his poem with this factor in order to demonstrate the resentment that he feels toward his father.   Ã‚  Ã‚  Ã‚  Ã‚  However, the last two lines of the poem suggest feelings other than resentment: "Then waltzed me off to bed/ Still clinging to your shirt" (Roethke 668). By mentioning the fact that his father put him to bed, Roethke seems to show affectionate feelings Bridges 2 involved in this dance. He shows his caring feelings in the last line by using the words "still clinging". "Certainly, this small boy's family life has its frightening side, but the last line suggests the boy is still clinging to his father with persistent if also complicated love" (Kennedy and Gioia 668). Although their dance appears to be "comic", Roethke seems to possess "an odd and ambivalent closeness" to his apparently intoxicated father (Balakian 62).   Ã‚  Ã‚  Ã‚  Ã‚  Still even more evidence of these mixed feelings is illustrated in the third stanza. "This love dance, a kind of blood rite between father and son, shows suppressed terror combined with awe-inspired dependency" (Balakian 62). "The hand that held my wrist/was battered on one knuckle;/ At every step you missed/ My right ear scraped a buckle"(Roethke 668). The speaker's father's hand being "battered on one knuckle" is indicative of a man who... ... quite demonstrative of how Bridges 5 powerful his feelings for his father must have been. "†¦Roethke tried, through careful revisions to balance negative and positive tones in 'My Papa's Waltz'" (McKenna 36).   Ã‚  Ã‚  Ã‚  Ã‚  Although the dance between him and his father was rough and aggressive, the very fact that Roethke chose to write about the waltz indicates that it is a special moment he remembers sharing with his father. The poet has a remarkable ability to describe the moment and not his feelings. This is what makes "My Papa's Waltz" so interesting and leaves so much to interpretation.   Ã‚  Ã‚  Ã‚  Ã‚   Works Cited Balakian, Peter. Theodore Roethke's Far Fields. Baton Rouge: Louisiana   Ã‚  Ã‚  Ã‚  Ã‚  State University Press, 1989. Gioia, Dana, & Kennedy, X. J. (Eds.). (1999). Literature: An Introduction to Fiction,   Ã‚  Ã‚  Ã‚  Ã‚  Poetry, and Drama. 7th Edition. New York, NY: Longman. McKenna, John J. "Roethke's Revisions and the Tone of 'My Papa's Waltz'". ANQ   Ã‚  Ã‚  Ã‚  Ã‚  Spring 1998: v11n2. Online. Galileo. 21 October 1999. Roethke, Theodore. "My Papa's Waltz"., Literature: An Introduction to Fiction, Poetry,   Ã‚  Ã‚  Ã‚  Ã‚  And Drama. Ed. X.J. Kennedy and Dana Gioia. 7th Ed. New York, NY:   Ã‚  Ã‚  Ã‚  Ã‚  Longman, 1999. 668.

We Need Stricter Laws for Drunk Driving (DUI) :: Argumentative, Persuasive Essays

Drunk driving is when an individual drives a vehicle with a blood alcohol concentration (BAC) level over the legaly permited limit. Driving under the influence of alcohol is a major health problem in the United States as it accounts for a high number of road fatalities; hence, there is a need for stricter drunk driving rules in the United States in order to reduce drunken driving fatalities. There is a need for the introduction and implementation of new drunk driving laws by the legislature, because presently the united States drunk driving laws are too lenient. The continuous rate of drunken driving fatalities makes a case that the united States drunk driving laws are too lenient and makes a call for stricter laws. According to Valenti â€Å"countries with strict drunk driving penalties have a far lower incidence of accidents than the United States (1). The United States being a first world country is weak in enforcing strict punishment for drunk drivers. Valenti is emphasizing on the fact that the united States need to improve their present laws and be firm in enforcing these new laws. There is a need for the United States to improve on their severity of its drunk driving penalties just the way the other part of the world have done and this is giving them a reduced rate of drunk driving fatalities. The claim of the leniency of the United States drunk driv ing laws is further stated by the National Highway Traffic Safety Administration (NHTSA), this is a prominent body when it comes to the issue of drunken driving fatalities. It claims that the drunken driving laws are severe enough. â€Å"Despite great strides in awareness, education and enforcement in the last two decades the United States still has one of the most lenient drunken driving standards in the world†. (NHTSA of existing laws. There is a need for stricter laws to be introduced as the United States ranks behind the world when it comes to effort to combat drunk driving and more efforts need to be put in place by the implementation of harsher laws so as to reduce the high rate of repeat offenders and first time offenders. The rate of repeat offenders is rising and the need to suppress this rate should be attended to immediately. Statistics supports the implementation of stricter rules, as the continual rate of the repeat offenders increases.

Brian Quinn

Dear Ms. Brummel: I have been involved in training clients and designing custom solution with Microsoft products for many years.  Ã‚  Ã‚   I would like the opportunity to see new Microsoft technologies first hand.   Specifically, I am writing to you about the System Administrator (Job code: XXXXXXX) and System Engineer ( Jobcode: 180703) positions I found while browsing the careers section of your website. I am a System Engineer specializing in Novell Netware and Windows 2000/2003 Active Directory.   For the last eight years, I ran a successful consulting business focusing on end-user training and Microsoft Systems support and administration.   Some of my former and current clients include: Onesoft Corporation, Novell, Oppenheimer Funds, Cal State Hayward, Energy Commission, Brigham Young University, Department of Justice, Franklin Covey and Anderson Consulting. In the course of pursuing my business interests I have acquired several professional certifications including: Microsoft Certified Systems Engineer , Microsoft Certified Trainer, Microsoft Certified Desktop Technician, Cisco Certified Network Associate( CCNA )and Novell Engineer.  Ã‚   I have 14 years of experience in the IT field; my previous employment is further detailed in the enclosed resume. I feel I can bring my extensive field and training experience to exceed the expectations for a person in the positions available.   I would like to speak with you at your convenience to discuss how I can contribute to Microsoft’s continued success.   I can be reached at (916)789-1779 any time. I look forward to hearing from you soon. Sincerely, Brian Quinn

Food and Safety Bulletin Essay

Public service bulletin, it has been reported to the city department of health on how the communicate is experiencing numerous of food-borne illnesses. However, the food-borne illnesses have raised some serious for the health department and in dealing with this illnesses the community needs to be educated on public food safety. Recognizing several common concerns connected to food purchase, storage, and presentation, explains several illnesses or crises the safety problem may affect to avoid the illnesses or crises and recommendation for where person who reads may search for more information. Include criteria that readers must use to determine creditable sources of information, explain why it is important for readers to use criteria when searching for information on nutrition (Wardlaw, Smith, 2009). Identify Common Safety Issues However, food poisoning can produce critical illness, but individuals can protect themselves and their family. In other word germs such as E.coli, salmonella, and listeria usually cause food poisoning. However, these pathogens usually relates with meat and fowl products, although the pathogens are capable of making their way into fresh produce through disaster or accidents while they are harvested, within the resource where they are managed or in local grocery store. Meanwhile, cheese may be contaminated with pathogens, but cheese and produce also has been subject as a food recall. * When shopping for groceries please consider recent recall items. Some stories may come through the news to reach community, so pay close attention to those stories, and remember them while making out a grocery list. Please be mindful that recall food take place on a regular basis however, recalls frequently affects a minor portion of food in certain area. * Before purchasing food inspect it as well as ma king sure meat, poultry, produce and cheese has its proper color and no detectable signs of grime. Pay attention to cheese and vegetables when attempting to eat raw however, cooking is simply a good way to go to be sure pathogens have been destroy. * One must store their poultry, meat, and cheese in the refrigerator or freezer as soon as they arrive home. However, the refrigerator must maintain a temperature less than 40 degrees and the freezer, however, has to maintain a temperatures of less than 32 degrees. Some produce items are not requiring being in the refrigerator but it is when the grocery store kept these specific food item at a cooler temperature. However, please keep in mind people should clean their vegetables thoroughly before cooking. Although it is not required to wash meat or poultry products prior to cooking, but always keep in mind to clean vegetables and wash their skins with a scrub brush prior to eating. * In addition, to this be sure to cook carefully as well as being mindful of cross-contamination threats each time a meal is prepared. Be sure to use d ifferent cutting boards and knives when cutting up meat and vegetables. Another important fact makes sure different cooking utensils are used for uncooked and cooked foods, mainly meats. Make certain everything he or she prepare to cook research a safe inside temperature that changes bases on the certain food item a person is cooking. Describe Illnesses or Problems Safety However, restoring the loss of fluid and electrolytes as well as maintaining the fluid intake are worthy. When cooking meat, poultry, and eggs please cook these products well-done. Cross contamination with food is not healthy way to cook which, means avoid cross-contaminating foods by means of washing hands, cooking tools, cutting boards after these utensils has been used for raw meat as well as poultry and prior to the of another food. Be sure to wash all produce. In other word, wash all fresh fruits and vegetables in running tap water to eliminate noticeable and unnoticeable grimes and dirt. At a room temperature bacteria can grow very fast, refrigerate food leftover if not eaten within four hours. Credible Source of Nutritional Information However, there is resource that community rely on such as MyPyramid.gov, WeightWatcher.com and MayoClinic.com however, these sites or very helpful for you and your family. It shows the portions amount one must content on their plate as well as their intake. This information would help the community understands the safety issues when grocery shopping and cooking different type of foods. References Michaelson, A. (2011, May ). How to Identtify Some Common Safety Issues Related to Food Purchase, Storage and Preparation. Retrieved February 5, 2012, from eHow.